Information for Physicians
Information for Physicians

Technical Documentation

Clinical Studies and Information

EDIM technology is a liquid biopsy for the determination of specific antigenes in immune cells. The use of the innate immune system allows an exceptional accuracy for diagnostics.

EDIM technology examines macrophages to detect antigens that have been phagocytosed by these immune cells previously – this is why we describe the technology as a biological biopsy. For this purpose, CD14 and CD16 surface antibodies are used, which bind specifically to the surface of the cells. The cells are then permeabilised briefly to induce further antibodies to enter the cells. These antibodies are directed against the antigens which are to be detected by the method. For example
in the case of RV Cancer Test, TKTL1 and Apo10
are inserted into the cells.

The cell structures on the surface of cells can be recognised very efficiently in blood samples with dye-labelled antibodies and a subsequent detection of these dyes by means of laser beams using the method of flow cytometry. This makes
it possible to recognise, count and further characterise macrophages in the blood. In this way, signals are also detected which are derived from bound antibodies in the cell interior. This makes it possible to detect what the phagocyte has detected and eliminated by phagocytosis.
If for example in the case of a tumor disease there are tumor cells in the organism, the system detects signals from the dyes that are coupled
to the TKTL1 and Apo10 antibodies.

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